Currently there is a well documented bug where players are still unable to progress through their faction reps and buy asmodeum chisels and make their own expedition keys. These players are forced to buy every single orb. There has not yet been any mention on the PTR notes they are addressing this. Due to the nature of the bug it is inevitable to occur to many players over the course of the game unless addressed. I am afraid with the purchasable mutator orbs these same players will have an additional orb they will not be able to acquire due to this bug.
Since this bug my friend has been forced to pay tens of thousands of gold to run expeditions since he has been locked from doing the keys himself. This is absolutely insane!